Machine learning generates pictures of proteins in 5D

Estimating 3D orientations and 2D positions of single molecules (SMs) using Deep-SMOLM. Credit: Optics Express (2022). DOI: 10.1364/OE.470146

By combining machine learning with the laws of physics, researchers in the lab of Matthew Lew, associate professor of electrical and systems engineering at Washington University in St. Louis, have been able to sort out the orientation and position of overlapping single molecules in 5D from a single image.

Their research was published Sept. 26 in the journal Optics Express.
The five dimensions in question aren’t new or hidden spatial dimensions. Instead, a team headed by Tingting Wu, a Ph.D. student in the …
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